PRELIMINARY PROGRAM
Wednesday PM
16:00 – 16:15 Welcome
Session 1: Phosphoinositide signaling & stress responses in cancer (Chair: Volker Haucke)
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16:15 – 16:45 Mariona Graupera (Josep Carreras Leukaemia Research Institute (Barcelona, Spain) "Behaviours of cancer-associated PI3K mutations in congenital mosaic syndromes"
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16:45 – 17:15 Lloyd Trotman (Cold Spring Harbor Laboratory, Cold Spring Harbor, USA) "Redox control of endocytosis for metastatic cancer therapy"
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17:15 – 17:30 Benoit Bilanges (University College London, London, UK) “Pharmacological activation of PI3Kα triggers cancer cell death under metabolic stress”
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17:30 – 17:45 Theodora A. Constantin (University of Basel, Basel, Switzerland) “Pharmacological Instant “Knockout” of PI3Kα Resolves Metabolic Response Thresholds”
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17:45 – 18:00 Julie Guillermet-Guibert (Centre de Recherches en Cancérologie de Toulouse, CRCT, Toulouse, France) “Pancreatic cancer cell adaptation to mechanical compressive stress reveals dynamics of class I PI3K activity and a targetable vulnerability”
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18:00 – 18:15 Sarah Conduit (University College London, London, UK) “Solid tumour cell-intrinsic function of PI3Kδ”
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18:15 – 18:30 Kseniia Golik (Toronto Metropolitan University, Toronto, Canada) “Akt out and find out: how clathrin modulates Akt isoform activation”
18:30 – 20:00 Dinner
20:00 - 20:10 Tribute to Ana Carrera presented by David Fruman
20:10 – 21:10 The Jacques E. Dumont keynote lecture (Chair: David Fruman)
Bart Vanhaesebroeck (University College London, London, UK)
“PI3K: 30+ years of discovery and translation”
21:00 Networking and discussion
Thursday AM
Session 2: Phosphoinositides in membrane contact site function (Chair: Bruno Goud)
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09:00 – 09:30 Jen Liou (Department of Physiology, UT Southwestern Medical Center, Dallas, USA)
“Phosphoinositide Signaling at Membrane Contact Sites”
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09:30 – 09:45 Cristina Camardi (Toronto Metropolitan University, Toronto, Canada) “The forgotten chain: LYCAT-mediated phosphoinositide acyl remodeling drives ER-PM contact site signaling to support breast cancer cell migration”
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09:45 – 10:00 Todd Graham (Vanderbilt University, Nashville, USA) “Control of Golgi PI4P homeostasis and COPI recruitment by a PI4P flippase”
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10:00 – 10:30 Emmanuelle Bayer (Laboratoire de Biogenèse Membranaire, Université de Bordeaux, France) "Crossing boundaries: Cell-cell Communication through membrane contact sites"
10:30 – 11:00 Coffee break
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11:00 – 11:30 Vytas Bankaitis (Texas A&M Health Science Center, College Station, USA) “An Atomistic Description of Lipid Exchange by a phosphatidylinositol Transfer Protein”
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11:30 – 12:00 Dorothea Fiedler (Leibniz Institute fur Molecular Pharmacologie, Berlin, Germany) “The multiple modes of action of inositol pyrophosphate messengers”
12:00- 14:00 Lunch
Thursday PM
14:00 – 18:30
Networking
18:30 – 20:00 Dinner
20:00 – 21:00 Keynote lecture (Chair: Bernard Payrastre)
Len Stephens (Babraham Institute, Cambridge, UK)
“PI3K signalling in prostate”
21:00 Poster Session 1
Friday AM
Session 3: Molecular mechanisms of phosphoinositide signaling & membrane recruitment (Chair: Bernard Payrastre)
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09:00 – 09:30 Jim Hurley (University of California, Berkeley, USA) “Writing and reading the PI3P signal in autophagy”
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09:30 – 10:00 John Burke (University of Victoria, Victoria, Canada) “Novel regulatory mechanisms that control membrane recruitment of the phosphoinositide kinases”
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10:00 – 10:15 Raymond D. Blind (Vanderbilt University School of Medicine and Medical Center, Nashville, USA) “Computed nuclear receptor phospholipid binding modes: using wet-lab yes/no binding data to train a categorical neural network”
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10:15 – 10:30 Daniel Lietha (Margarita Salas Center for Biological Research (CIB), Spanish National Research Council (CISC), Madrid, Spain) “Structural insights into clustered membrane signaling provide basis for high signal output and enable alternative targeting strategies”
10:30 – 11:00 Coffee break
Session 4: PIKfyve functions in health and disease (Chair: Christoph Fahlke)
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11:00 – 11:30 Lois Weisman (Life Sciences Institute, University of Michigan, USA) “Regulation of PIKfyve on Dynamic Endosomes Promotes Cell Migration"
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11:30 – 11:45 Ilona Willson (The University of Sheffield, Sheffield, UK) “A Mechanistic Understanding of PIKfyve Signalling During Phagosome Maturation”
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11:45 – 12:00 Hélène Tronchere (Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR1297, Toulouse, France) “PIKfyve regulates endolysosomal and mitochondrial function in cardiomyocytes. Implication for heart failure”
12:00 - 14:00 Lunch
Friday PM
Session 5: "Phosphoinositide signaling in nuclear functions and genome integrity" (Chair: Ray Blind)
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14:00 – 14:30 Ganna Panasyuk (Institut Necker-Enfants Malades (INEM), Paris, France) "Class 3 PI3K and PI3P: From cytosolic roles to nuclear transcription"
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14:30 – 15:00 Emilio Hirsch (University of Torino, Torino, Italy) "Spatial Control of Phosphoinositides Safeguards Cytokinesis and Genome Integrity"
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15:00 – 15:20 Richard Anderson (University of Wisconsin, Madison, USA) “Phosphoinositide Lipids Linked to Proteins Represent a 3rd Messenger Pathway”
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15:20 – 15:40 Nullin Divecha (University of Southampton, Southampton, UK) “Targeting nuclear Phosphoinositide interacting PHD fingers in Acute myeloid leukaemia”
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15:40 – 15:55 Nadia Gillet (IRIBHM Jacques E. Dumont, ULB/Faculty of Medicine, Brussels, Belgium) “SHIP2 maintains mitotic integrity and represents a synthetic lethal vulnerability in p53-deficient Esophageal squamous cell carcinoma”
15:55 – 16:30 Coffee break
Session 6: Spatio-temporal control of phosphoinositide pools in membrane dynamics (Chair: Richard Anderson)
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16:30 – 17:00 Volker Haucke (Leibniz Institute fur Molecular Pharmacologie, Berlin, Germany) “Lipid signaling in health and disease: From organelles to brain function”
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17:00 – 17:30 Gerry Hammond (University of Pittsburgh School of Medicine, Pittsburgh, USA) “Not so happy together: single molecule imaging of class 1A PI3K subunit activation in the living cell”
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17:30 – 17:45 Raghu Padinjat (National Centre for Biological Sciences-TIFR, Bangalore, India) “Phosphatidylinositol 5 phosphate 4 kinase regulates phosphatidylinositol 3,4 bisphosphate levels in vivo”
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17:45 – 18:00 Francesca Cervellini (Telethon Institute of Genetics and Medicine, TIGEM, Pozzuoli, Naples, Italy) “OCRL Regulates a Novel PI(4,5)P₂ Pool on Lipid Droplets Essential for Fatty Acid Metabolism and Mitochondrial Function”
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18:00 – 18:15 Natalie Uzynski (Toronto Metropolitan University, Toronto, Canada) “A PIP-ing Hotspot for PI3K-Akt Signaling within Clathrin Signalosomes”
18:30- 20:00 Dinner
20:00 – 21:00 Keynote lecture (Chair: TBD)
Maria Antonietta De Matteis (Telethon Institute of Genetics and Medicine, TIGEM, Pozzuoli, Naples, Italy)
"A PIPeline for drug discovery in Lowe syndrome"
21:00 Poster Session 2
Saturday AM
Session 7: Phosphoinositide signaling in health and human disease (Chair: Julie Guillermet-Guibert)
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09:00 – 09:30 Julien Viaud (Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR1297, Toulouse, France) "MTM1-dependent phosphoinositide remodeling regulates endosomal trafficking and integrin dynamics in XLMTM"
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09:30 – 09:45 Lalita Oparija-Rogenmozere (University of Basel, Basel, Switzerland) “Two PI3Kg Complexes Drive Distinct Metabolic Disease Phenotypes”
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09:45 – 10:00 Isra Mentouri (Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR1297, Toulouse, France) “Differential contributions of PI3Kγ adaptor complexes to atherosclerosis: p101-p110γ as a precision target for foam cell formation”
10:00– 10:30 Coffee break
10:30– 11:30 Keynote lecture (Chair: Julien Viaud)
Takehiko Sasaki (Medical Research Laboratory, Institute of Science Tokyo, Tokyo, Japan) “Phosphoinositide Remodeling as a Regulatory Axis in Aging and Disease”
11:30 - 12:00 Poster awards ceremony
& conclusions
Picnic pickup and departure at 13:00
